課程資訊
課程名稱
基因體研究特論
Special Topics in Genomic Studies 
開課學期
106-1 
授課對象
共同教育中心  統計碩士學位學程  
授課教師
郭柏秀 
課號
EPM7181 
課程識別碼
849 M0750 
班次
 
學分
2.0 
全/半年
半年 
必/選修
選修 
上課時間
星期三3,4(10:20~12:10) 
上課地點
公衛209 
備註
生醫資訊與生物統計領域選修課程之一。與張弘潔、林菀俞、盧子彬合授
限碩士班以上
總人數上限:15人 
Ceiba 課程網頁
http://ceiba.ntu.edu.tw/1061EPM7181_ 
課程簡介影片
 
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課程概述

The major goal of this course is to learn the concepts, new methods and findings of a wide-range of topics in genomic studies through reading and discussion of original articles. Selected articles of each topic have a major theme and involved various issues commonly encountered in genomic studies. Course will begin with an introductory lecture to point out important issues. Students are expected to read assigned articles in advance and discuss the designated questions during class. We’ll cover topics related to a) Study design, data analysis and integration; b) Assessment of human genome variation and regulation; c) Using genomic information in medicine and public health; and d) Ethical issues in using genomic data. 

課程目標
1. To learn the concepts, new methods and findings of a wide-range of topics in genomic studies.
2. To learn how to read critically original articles in genomic studies.
 
課程要求
[具備基礎遺傳學知識,或修習過遺傳流行病學原理、其他授課教師認可之遺傳相關課程]
Class participation: including presentation and discussion.
Assignments: written discussion about the designated questions listed in each session.
Final report: choose a topic and describe concisely the design, main findings, unsolved problems, and future directions of studies in the field.
 
預期每週課後學習時數
 
Office Hours
另約時間 
指定閱讀
 
參考書目
Human Genome Epidemiology, 2nd Edition

Building the evidence for using genetic information to improve health and
prevent disease.

Edited by
Muin Khoury, Sara Bedrosian, Marta Gwinn, Julian Higgins, John Ioannidis,
and Julian Little 
評量方式
(僅供參考)
 
No.
項目
百分比
說明
1. 
Class participation 
50% 
 
2. 
Class assignments 
20% 
 
3. 
Final report 
30% 
 
 
課程進度
週次
日期
單元主題
第1週
09/13  Course introduction and introduction of genomic epidemiology  
第2週
09/20  Genome-wide association studies 
第3週
09/27  Risk prediction 
第4週
10/04  Mid-Autumn Festival (holiday) 
第5週
10/11  Pharmacogenomics (調課10/03 or 10/05) 
第6週
10/18  Rare variants introduction (盧子彬) 
第7週
10/25  Common and rare variants in public health applications 
第8週
11/01  Rare variants analysis (林菀俞) 
第9週
11/08  Incorporating interactions 
第10週
11/15  Anniversary celebration of NTU (holiday) 
第11週
11/22  Epigenetics 
第12週
11/29  Gene expression and -omic data 
第13週
12/06  Pathway-based analysis 
第14週
12/13  Ethical issues in using genomic data (張弘潔) 
第15週
12/20  Metagenomics 
第16週
12/27  Final presentation (盧子彬) 
第17週
01/03  Final presentation (盧子彬)